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Title:

Impact of dry coating on dissolution profile of micronized BCS class II drugs: Influence of coating material hydrophobicity

Discipline: Chemical Engineering

Presenter:

Sangah Kim

Abstract:

BCS Class II drugs exhibit low solubility, leading to slow and poor absorption. One way to overcome this issue is the micronization. However, such fine particles tend to agglomerate, negating the benefits of micronization. Simultaneous micronization–dry coating and dry coating of micronized drug particles have been shown to be effective for reducing the extent of agglomeration and increasing the surface area of drug particles. While previous investigations focused on the impact of dry coating on drug particle agglomeration and dissolution enhancement, the impact of coating material on the surface hydrophobicity of drug particles has not been examined. Hence, the current study aims to examine the impact of hydrophobicity of the applied dry-coating material on the dissolution rate of selected BCS class II drugs. Griseofulvin (d50 of 10 µm) and Ibuprofen (d50 of 20 µm) were selected as model drugs. Each drug was dry coated with either hydrophilic (A200) or hydrophobic (R972P) fumed silica and theoretical calculations were used to select the amount of coating material required to cover surface area of the APIs. Compiled results show that the hydrophobicity of the applied coating material significantly affects the wettability of the drug powder and thus the dissolution profiles.

Author(s):

Sangah Kim, Liang Chen, Kuriakose Kunnath, Ecevit Bilgili, Rajesh Dave

Funding Acknowledgements:

National Science Foundation (NSF) grants # EEC-0540855 and IIP-1919037; NJIT Provost Fellowship